Welcome to the Biotage Scale Up Blogs.

      How to add metal scavenging steps into a workflow to maximize metals removal

      Sep 19, 2022 2:00:00 PM / by Sunil Rana posted in ISOLUTE, metal scavenger, palladium, Si-TMT, Pd catalyst, Suzuki reaction

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      Once a chemist has seen and understands potential for the application of metal scavenging and reduction of classical iterative metal migration steps, the next question I usually receive, relates to how best to apply them to a reaction.

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      Metal Scavengers: An alternative to recrystallization for removing metals?

      Aug 29, 2022 2:00:00 PM / by Sunil Rana posted in ISOLUTE, metal scavenger, palladium, Si-TMT, Pd catalyst

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      In this blog, I will address something that is fundamental to years of classic process chemistry techniques. First disclaimer is that the pharma industry uses recrystallization for several purposes, nearly always for the creation of purer product and sometimes in connection with isolation of specific crystalline forms.

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      Exploding the myth about loading capacity and metal scavengers

      Jul 18, 2022 2:00:00 PM / by Sunil Rana posted in palladium, screening, Oxford, Si-TMT, biological assays, Pd, medchem, impurities, Wynne, CEMAS

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      Once a chemist has seen and understands potential for the application of metal scavenging and reduction of classical iterative metal migration steps, the next question we receive usually relates to how best to apply them to a reaction.

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      Can biological assay results be trusted if your sample is contaminated with Pd?

      Jun 27, 2022 8:14:09 AM / by Tim Jones posted in palladium, screening, Oxford, Si-TMT, biological assays, Pd, medchem, impurities, Wynne, CEMAS

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      I recently read an interesting paper from Graham Wynne and his many collaborators at the University of Oxford and CEMAS describing just how much residual palladium (Pd) is making its way through the standard purification processes employed by medicinal chemists.

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