Welcome to the Biotage Scale Up Blogs.

      Are metal scavengers better than carbon?

      Aug 8, 2022 2:00:00 PM / by Sunil Rana posted in efficiency, palladium, Pd, carbon, yield, activated, cleaning, Si-Thiol, batch reactor, recrystallization

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      After my seminars, I often receive questions from astute attendees on the topic of activated carbon, and how the more modern powerful approach of metal scavenging compares to the traditional application of activated carbon. This can be an emotive topic, sometimes the question can be a blunt as ‘What’s wrong with carbon? It’s the way most process groups have historically removed transition metals such as palladium.'

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      Exploding the myth about loading capacity and metal scavengers

      Jul 18, 2022 2:00:00 PM / by Sunil Rana posted in palladium, screening, Oxford, Si-TMT, biological assays, Pd, medchem, impurities, Wynne, CEMAS

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      Once a chemist has seen and understands potential for the application of metal scavenging and reduction of classical iterative metal migration steps, the next question we receive usually relates to how best to apply them to a reaction.

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      Can biological assay results be trusted if your sample is contaminated with Pd?

      Jun 27, 2022 8:14:09 AM / by Tim Jones posted in palladium, screening, Oxford, Si-TMT, biological assays, Pd, medchem, impurities, Wynne, CEMAS

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      I recently read an interesting paper from Graham Wynne and his many collaborators at the University of Oxford and CEMAS describing just how much residual palladium (Pd) is making its way through the standard purification processes employed by medicinal chemists.

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