There are two starting points, depending on your preference of whether you want to stir in a batch or flow something though a tube. If you plan to use large scale up reactors, then batch stir methods are great, but if you imagine wanting to flow material through a ‘cleaning’ column, then the SPE quick test works well.

Now we have a screening candidate, we just need to scale up our work, it is always advisable to initially to scale in factors of ~10 in our experience, although for well-used processes and repetitive batch processing, it is possible to screen grams and go straight to Kgs.