Welcome to the Biotage Scale Up Blogs.

      Are metal scavengers better than carbon?

      Aug 8, 2022 2:00:00 PM / by Sunil Rana posted in efficiency, palladium, Pd, carbon, yield, activated, cleaning, Si-Thiol, batch reactor, recrystallization

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      After my seminars, I often receive questions from astute attendees on the topic of activated carbon, and how the more modern powerful approach of metal scavenging compares to the traditional application of activated carbon. This can be an emotive topic, sometimes the question can be a blunt as ‘What’s wrong with carbon? It’s the way most process groups have historically removed transition metals such as palladium.'

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      Exploding the myth about loading capacity and metal scavengers

      Jul 18, 2022 2:00:00 PM / by Sunil Rana posted in palladium, screening, Oxford, Si-TMT, biological assays, Pd, medchem, impurities, Wynne, CEMAS

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      Once a chemist has seen and understands potential for the application of metal scavenging and reduction of classical iterative metal migration steps, the next question we receive usually relates to how best to apply them to a reaction.

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      Can biological assay results be trusted if your sample is contaminated with Pd?

      Jun 27, 2022 8:14:09 AM / by Tim Jones posted in palladium, screening, Oxford, Si-TMT, biological assays, Pd, medchem, impurities, Wynne, CEMAS

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      I recently read an interesting paper from Graham Wynne and his many collaborators at the University of Oxford and CEMAS describing just how much residual palladium (Pd) is making its way through the standard purification processes employed by medicinal chemists.

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      What is metal scavenging and what are metal scavengers?

      Oct 19, 2021 2:19:58 PM / by Biotage posted in metal scavenger, mp-tmt, palladium

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      Whether for pharma, fine chemical, agrochemical, electronic or natural product research, in recent years, there has been increasing pressure to achieve and deliver higher purity products. Chemical products derived from various synthetic chemistry approaches carry with them an inherent risk of by-products and therefore contamination can be a big problem. Potential contaminants are numerous and can be solvent, reagent or catalyst derived...

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      How to Remove Palladium in three easy steps

      May 6, 2020 3:37:11 PM / by Sunil Rana posted in Troubleshooting and Optimization, Scale-Up, Scavenger, metal scavenger key article

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      Introduction

      Removing palladium has become more and more difficult for a number of reasons.  Industry is using it more frequently, due to its greener credentials as a catalyst but regulatory bodies are also reducing acceptable limits in APIs.  One of the most significant changes for pharma recently has been increased scrutiny of impurities in pharma products.

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      Practical Lab methods for the development of metal removal processes

      May 6, 2020 3:36:29 PM / by Sunil Rana posted in Scale-Up, Scavenger, metal scavenger key article

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      There are two starting points, depending on your preference of whether you want to stir in a batch or flow something though a tube. If you plan to use large scale up reactors, then batch stir methods are great, but if you imagine wanting to flow material through a ‘cleaning’ column, then the SPE quick test works well.

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      Scaling-up with Metal Scavengers

      May 6, 2020 3:33:48 PM / by Sunil Rana posted in Scavenger, metal scavenger key article

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      Now we have a screening candidate, we just need to scale up our work, it is always advisable to initially to scale in factors of ~10 in our experience, although for well-used processes and repetitive batch processing, it is possible to screen grams and go straight to Kgs.

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