Removing palladium has become more and more difficult for a number of reasons. Industry is using it more frequently, due to its greener credentials as a catalyst but regulatory bodies are also reducing acceptable limits in APIs. One of the most significant changes for pharma recently has been increased scrutiny of impurities in pharma products.
There are two starting points, depending on your preference of whether you want to stir in a batch or flow something though a tube. If you plan to use large scale up reactors, then batch stir methods are great, but if you imagine wanting to flow material through a ‘cleaning’ column, then the SPE quick test works well.
Now we have a screening candidate, we just need to scale up our work, it is always advisable to initially to scale in factors of ~10 in our experience, although for well-used processes and repetitive batch processing, it is possible to screen grams and go straight to Kgs.
