Welcome to the Biotage Scale Up Blogs.

      How to Remove Palladium in three easy steps

      May 6, 2020 3:37:11 PM / by Sunil Rana posted in Troubleshooting and Optimization, Scale-Up, Scavenger, metal scavenger key article

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      Introduction

      Removing palladium has become more and more difficult for a number of reasons.  Industry is using it more frequently, due to its greener credentials as a catalyst but regulatory bodies are also reducing acceptable limits in APIs.  One of the most significant changes for pharma recently has been increased scrutiny of impurities in pharma products.

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      Practical Lab methods for the development of metal removal processes

      May 6, 2020 3:36:29 PM / by Sunil Rana posted in Scale-Up, Scavenger, metal scavenger key article

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      There are two starting points, depending on your preference of whether you want to stir in a batch or flow something though a tube. If you plan to use large scale up reactors, then batch stir methods are great, but if you imagine wanting to flow material through a ‘cleaning’ column, then the SPE quick test works well.

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      Scaling-up with Metal Scavengers

      May 6, 2020 3:33:48 PM / by Sunil Rana posted in Scavenger, metal scavenger key article

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      Now we have a screening candidate, we just need to scale up our work, it is always advisable to initially to scale in factors of ~10 in our experience, although for well-used processes and repetitive batch processing, it is possible to screen grams and go straight to Kgs.

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