Welcome to the Biotage Scale Up Blogs.

      How to Scale-Up Normal-Phase Purification

      Sep 22, 2015 2:48:21 AM / by Bob Bickler posted in Chromatography Fundamentals, Reversed-phase, Scale-Up, Normal Phase, Pillar Page, sca flash key articles

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      For chemists performing bench-scale organic synthesis, flash column chromatography is often the primary purification technique.  When synthesis needs scaling to multi-gram levels, so does the flash purification. The logical approach is to increase the flash cartridge or column size, but this is only part of the solution.  In this article we discuss the process of simplifying flash purification scale-up.

      Scaling-up flash chromatography can seem a daunting task but it is a fairly straightforward process once the following parameters are determined:

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      How to Scale-Up Reversed Phase Flash Purification

      Nov 17, 2014 10:32:37 AM / by Greg Saunders posted in Chromatography Fundamentals, Reversed-phase, Scale-Up, Normal Phase, Pillar Page, sca flash key articles

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      Chemists are often taught how to use glass columns in schools, so they take fundamental background experience into industry which provides an intuitive advantage in process development applications.  However, with the exception analytical RP-HPLC, there is usually relatively little experience of preparative scale reversed phase purification.

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