Welcome to the Biotage Scale Up Blogs.

      Collaborating with Croda in the global COVID-19/ mRNA vaccine response

      Nov 12, 2021 5:00:01 PM / by Biotage posted in sca flash key articles, Flash 400, API, case study, mRNA, COVID

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      There are fantastic global efforts to fight the spread of COVID-19 through therapies and vaccines and there is much research ongoing on optimizing the vital benefits that can be conferred by these innovative ideas.  One of the most encouraging ideas from recent years involves the use of mRNA (messenger RNA).  Some COVID-19 vaccines are based on mRNA (which code for structures that are in, or look similar to the viral proteins and thus can be more readily and safety identified by the defence mechanisms of the cell).  However, these often require complex formulations for delivery and maximum stability.  This is because mRNA by itself is relatively fragile and needs protecting from being broken down once in the body.

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      Biotage® Flash 400 reduces process costs by 50% in a greener more efficient API purification project at CordenPharma Switzerland

      Oct 27, 2021 3:34:22 PM / by Biotage posted in sca flash key articles, Flash 400, API, case study

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      Large-scale chromatography is often the only solution to the purification of valuable drug compounds in the pharmaceutical industry. For many manufacturers, bespoke chromatography solutions seem the simplest
      and most efficient way of implementing such techniques, utilizing the specialist knowledge of in-house chemical engineers to create a custom solution. However, there are numerous drawbacks to such an approach.
       In many cases, a commercially available purification system specifically designed for a manufacturing environment represents an attractive alternative....

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