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      Bob Bickler

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      Lipids for LNP Formulations – Flash Chromatography Purification Options

      Mar 9, 2021 2:39:54 PM / by Bob Bickler posted in liquid chromatography, Nanoparticle, Lipid


      COVID-19 caused accelerated research into developing vaccine options. Some of the created vaccines are based on mRNA which, if not protected, easily degrades in humans before its therapeutic benefits can be realized.

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      How to Scale-Up Normal-Phase Purification

      Sep 22, 2015 2:48:21 AM / by Bob Bickler posted in Chromatography Fundamentals, Reversed-phase, Scale-Up, Normal Phase, Pillar Page, sca flash key articles


      For chemists performing bench-scale organic synthesis, flash column chromatography is often the primary purification technique.  When synthesis needs scaling to multi-gram levels, so does the flash purification. The logical approach is to increase the flash cartridge or column size, but this is only part of the solution.  In this article we discuss the process of simplifying flash purification scale-up.

      Scaling-up flash chromatography can seem a daunting task but it is a fairly straightforward process once the following parameters are determined:

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