Welcome to the Biotage Scale Up Blogs.

      Fast-Track Flash Purification projects

      May 11, 2020 12:49:29 PM / by Sunil Rana posted in Selekt, Scale-Up, Normal Phase, Corporate

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      Biotage is a leading global provider of equipment for drug discovery, life sciences and various chemical industries.  Our products serve a range of clients in diverse applications, from purification of the latest fast-tracked targets in times of need through to pharmaceutical research for the next blockbuster.  We are especially proud to help now but have also been helping to improve research supporting increased quality of life for people and our planet for over 30 years.

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      Introduction: How to Effectively Scale-Up Flash Purification

      Apr 16, 2020 2:12:07 PM / by Sunil Rana posted in Chromatography Fundamentals, Reversed-phase, Scale-Up, Normal Phase, sca flash key articles

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      Scale-up is a topic of paramount importance in the industry, drawing on inputs from safety, economic, regulatory and efficiency perspectives.  Never before has so much attention focussed on chemical synthesis and workflow.  The topic of scale-up is diverse but at its fundamental level, aims to fashion economically viable outputs from simple lab techniques and exploration based on the solid ground of scientific first principles.  On scale-up; we often switch evaporation for crystallization, convert overnight lab-scale ‘convenience’ reactions to more effective sequences, think about whether those heat and energy inputs are really necessary, risk assess for runaways etc but how should we handle purification?

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      How to Scale-Up Normal-Phase Purification

      Sep 22, 2015 2:48:21 AM / by Bob Bickler posted in Chromatography Fundamentals, Reversed-phase, Scale-Up, Normal Phase, Pillar Page, sca flash key articles

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      For chemists performing bench-scale organic synthesis, flash column chromatography is often the primary purification technique.  When synthesis needs scaling to multi-gram levels, so does the flash purification. The logical approach is to increase the flash cartridge or column size, but this is only part of the solution.  In this article we discuss the process of simplifying flash purification scale-up.

      Scaling-up flash chromatography can seem a daunting task but it is a fairly straightforward process once the following parameters are determined:

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      How to Scale-Up Reversed Phase Flash Purification

      Nov 17, 2014 10:32:37 AM / by Greg Saunders posted in Chromatography Fundamentals, Reversed-phase, Scale-Up, Normal Phase, Pillar Page, sca flash key articles

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      Chemists are often taught how to use glass columns in schools, so they take fundamental background experience into industry which provides an intuitive advantage in process development applications.  However, with the exception analytical RP-HPLC, there is usually relatively little experience of preparative scale reversed phase purification.

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