Welcome to the Biotage Scale Up Blogs.

      Flash Chromatographic Purification of Cannabicitran (CBCT)

      Nov 3, 2020 1:49:31 PM / by Bob Bickler posted in Reversed-phase, purification, Cannabinoids

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      Cannabicitran is one of many minor cannabinoids found in cannabis though not much is known about this compound as far as possible medicinal benefits.

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      What is the Best Way to Isolate CBDA from Hemp?

      Oct 6, 2020 1:44:55 PM / by Bob Bickler posted in CBDA, purification

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      Cannabidiolic acid, or CBDA, has purported analgesic properties relieving pain and inflammation[1]. CBDA is also the starting material for CBD which is produced through a procedure called decarboxylation using heat but which can also degrade CBD generating yield losses[2].

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      How to efficiently remove water from cannabinoid chromatography fractions

      Sep 8, 2020 2:36:37 PM / by Bob Bickler posted in Cannabis, Reversed-phase, Media and Resin

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      Cannabinoid isolation requires several steps from harvesting the biomass to extraction, winterization, decarboxylation (if desired), distillation, and finally chromatographic purification and isolation of the desired cannabinoids. It is during the chromatography step where water is introduced which, as we all know, can be challenging to remove from the desired cannabinoid by distillation or other evaporative technologies.

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      How can I determine which cannabinoid I am collecting when using flash chromatography?

      Jul 28, 2020 4:53:06 PM / by Bob Bickler posted in Cannabis, Detector, UV

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      Flash chromatography is the go-to cannabinoid purification technique because of its effectiveness and relative ease of use. This technology can easily remove THC from CBD in a process known as THC remediation. Flash chromatography is also used to separate and isolate other cannabinoids as well (CBN, CBC, CBG, CBDA, CBCT, etc.).

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      Flash Chromatographic Purification of Cannabichromene (CBC)

      May 20, 2020 2:03:50 PM / by Bob Bickler posted in Cannabis, Reversed-phase, Sfär, Normal Phase

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      Cannabichromene (CBC) is one of the four most prevalent cannabinoids expressed by cannabis plants (Pollastro, 2018). Unlike the psychoactive tetrahydrocannabinol, CBC is benign in this regard, but does have purported health benefits.

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      CBN Purification by Flash Chromatography

      Apr 30, 2020 5:16:00 PM / by Bob Bickler posted in Cannabis, Reversed-phase

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      Cannabidiol or CBN, is a cannabinoid of interest because of its potential in medicinal applications. However, CBN is not expressed by cannabis plants in high yields and is actually formed from degraded (oxidized) tetrahydrocannabinol (THC).

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      CBG Purification by Flash Chromatography

      Apr 28, 2020 5:12:36 PM / by Bob Bickler posted in Cannabis, Reversed-phase

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      As one of the major cannabinoids present in cannabis, Cannabigerol (CBG), is gaining interest as possible therapeutic. Though all other cannabinoids are created from CBGA (the acid form of CBG), it is metabolized to CBG and then primarily to THC or CBD, depending on the plant species.

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      How can I purify CBN from a cannabinoid mixture?

      Mar 10, 2020 4:40:29 PM / by Bob Bickler posted in Cannabis, Chromatography Fundamentals, Reversed-phase

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      In recent years, most of the interest in the medicinal cannabis market  has been focused on CBD (THC-free) and, to a lesser extent, THC. However, the market needs are changing with increasing interest now seen in the so-called minor cannabinoids. In this post, I will focus on cannabinol (CBN).

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      Introduction: A guide to the process of CBD and THC remediation for medicinal applications

      Nov 26, 2019 11:50:26 AM / by Sunil Rana posted in Cannabis, Reversed-phase, Cost

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      This article contains information relating to the science, process and economics of CBD and THC processing.

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      Biological Activity and Therapeutic benefits of CBD and THC

      Nov 26, 2019 11:49:58 AM / by Biotage posted in Cannabis, cannabis key article

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      Here is an overview of the biology and some of the terms that are used in this industry, and that you will see referred to many times.  After that, we'll then look at what makes these plant extracts so unique.

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